Thymic stromal lymphopoietin signaling in CD4+ T cells is required for TH2 memory
Background Thymic stromal lymphopoietin (TSLP) is a key factor in the development of
allergic asthma. Numbers of TH 2 memory cells gradually increase in allergic patients with
the progression of disease and persist in the lungs during remission, although the
mechanism is not clear. Objective We sought to define the role of TSLP in TH 2 memory cell
generation and maintenance in vivo. Methods Adoptive transfer of wild-type and thymic
stromal lymphopoietin receptor (TSLPR)–deficient ovalbumin-specific CD4+ T cells before …
allergic asthma. Numbers of TH 2 memory cells gradually increase in allergic patients with
the progression of disease and persist in the lungs during remission, although the
mechanism is not clear. Objective We sought to define the role of TSLP in TH 2 memory cell
generation and maintenance in vivo. Methods Adoptive transfer of wild-type and thymic
stromal lymphopoietin receptor (TSLPR)–deficient ovalbumin-specific CD4+ T cells before …