[HTML][HTML] GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen
A Sheih, WC Parks, SF Ziegler - Mucosal immunology, 2017 - Elsevier
Airway epithelial cells are among the first to encounter inhaled allergens and can initiate
allergic responses by producing pro-Th2 innate cytokines. In this study, we investigated the
role of epithelial-derived cytokines in sensitization to a clinically relevant allergen, cockroach
allergen (CRA). Among the epithelial-derived cytokines, granulocyte macrophage colony-
stimulating factor (GM-CSF) had a central role in the initiation of Th2 allergic responses to
CRA. We show that initial exposure to CRA directly activated airway epithelial cells through …
allergic responses by producing pro-Th2 innate cytokines. In this study, we investigated the
role of epithelial-derived cytokines in sensitization to a clinically relevant allergen, cockroach
allergen (CRA). Among the epithelial-derived cytokines, granulocyte macrophage colony-
stimulating factor (GM-CSF) had a central role in the initiation of Th2 allergic responses to
CRA. We show that initial exposure to CRA directly activated airway epithelial cells through …