Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge
SK Ahuja, MS Manoharan, NL Harper… - Journal of Allergy and …, 2017 - Elsevier
Background An emerging paradigm holds that resistance to the development of allergic
diseases, including allergic rhinoconjunctivitis, relates to an intact epithelial/epidermal
barrier during early childhood. Conceivably, the immunologic and genomic footprint of this
resistance is preserved in nonatopic, nonallergic adults and is unmasked during exposure to
an aeroallergen. Objective The aim of this study was to obtain direct support of the
epithelial/epidermal barrier model for allergic rhinoconjunctivitis. Methods Twenty-three …
diseases, including allergic rhinoconjunctivitis, relates to an intact epithelial/epidermal
barrier during early childhood. Conceivably, the immunologic and genomic footprint of this
resistance is preserved in nonatopic, nonallergic adults and is unmasked during exposure to
an aeroallergen. Objective The aim of this study was to obtain direct support of the
epithelial/epidermal barrier model for allergic rhinoconjunctivitis. Methods Twenty-three …