The role of ILC2 in pathology of type 2 inflammatory diseases
JH Bernink, K Germar, H Spits - Current opinion in immunology, 2014 - Elsevier
JH Bernink, K Germar, H Spits
Current opinion in immunology, 2014•ElsevierHighlights•ILC2 are emerging as key regulators and effectors in type 2 immunity and tissue
repair.•ILC2 play critical roles in the early stages of a protective immune response against
helminthic parasites.•ILC2 promote Th2 cells either by direct cross-talking with T cells or by
recruiting DC that induce Th2.•ILC2 are key regulators of eosinophils through production of
IL-5.Group 2 innate lymphoid cells (ILC2) which are strategically interspersed throughout
barrier surfaces are important regulators of type 2 immune reactions, particularly against …
repair.•ILC2 play critical roles in the early stages of a protective immune response against
helminthic parasites.•ILC2 promote Th2 cells either by direct cross-talking with T cells or by
recruiting DC that induce Th2.•ILC2 are key regulators of eosinophils through production of
IL-5.Group 2 innate lymphoid cells (ILC2) which are strategically interspersed throughout
barrier surfaces are important regulators of type 2 immune reactions, particularly against …
Highlights
- ILC2 are emerging as key regulators and effectors in type 2 immunity and tissue repair.
- ILC2 play critical roles in the early stages of a protective immune response against helminthic parasites.
- ILC2 promote Th2 cells either by direct cross-talking with T cells or by recruiting DC that induce Th2.
- ILC2 are key regulators of eosinophils through production of IL-5.
Group 2 innate lymphoid cells (ILC2) which are strategically interspersed throughout barrier surfaces are important regulators of type 2 immune reactions, particularly against helminthic parasites. ILC2 are also involved in tissue homeostasis and repair. Studies in a variety of animal models have demonstrated that when dysregulated or chronically activated, ILC2 can contribute to the pathology of allergic inflammatory diseases such as allergic asthma and atopic dermatitis. Here we discuss new findings of the cross talk of ILC2 with other hematopoietic cells, in particular T cells, and review recent information on the role of ILC2 in type 2 inflammatory diseases.
Elsevier