Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids
J Wu, C Zheng, Y Fan, C Zeng, Z Chen… - Journal of the …, 2014 - journals.lww.com
MicroRNAs (miRNAs) are essential for podocyte homeostasis, and the miR-30 family may
be responsible for this action. However, the exact roles and clinical relevance of miR-30s
remain unknown. In this study, we examined the expression of the miR-30 family in the
podocytes of patients with FSGS and found that all members are downregulated. Treating
cultured human podocytes with TGF-β, LPS, or puromycin aminonucleoside (PAN) also
downregulated the miR-30 family. Podocyte cytoskeletal damage and apoptosis caused by …
be responsible for this action. However, the exact roles and clinical relevance of miR-30s
remain unknown. In this study, we examined the expression of the miR-30 family in the
podocytes of patients with FSGS and found that all members are downregulated. Treating
cultured human podocytes with TGF-β, LPS, or puromycin aminonucleoside (PAN) also
downregulated the miR-30 family. Podocyte cytoskeletal damage and apoptosis caused by …