[HTML][HTML] Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis
GA McMahon, E Petitclerc, S Stefansson… - Journal of Biological …, 2001 - ASBMB
Elevated expression of plasminogen activator inhibitor-1 (PAI-1) in tumors is associated with
a poor prognosis in many cancers. Reduced tumor growth and angiogenesis have also
been reported in mice deficient in PAI-1. These results suggest that PAI-1 may be required
for efficient angiogenesis and tumor growth. In the present study, we demonstrate that PAI-1
can both enhance and inhibit the growth of M21 human melanoma tumors in nude mice and
that this appears to be due to PAI-1 regulation of angiogenesis. Quantitative analysis of …
a poor prognosis in many cancers. Reduced tumor growth and angiogenesis have also
been reported in mice deficient in PAI-1. These results suggest that PAI-1 may be required
for efficient angiogenesis and tumor growth. In the present study, we demonstrate that PAI-1
can both enhance and inhibit the growth of M21 human melanoma tumors in nude mice and
that this appears to be due to PAI-1 regulation of angiogenesis. Quantitative analysis of …