[HTML][HTML] Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study
L Hodson, L Bhatia, E Scorletti, DE Smith… - European journal of …, 2017 - nature.com
L Hodson, L Bhatia, E Scorletti, DE Smith, NC Jackson, F Shojaee-Moradie, M Umpleby…
European journal of clinical nutrition, 2017•nature.comResults: Nine participants were stratified to DHA⩾ 2%(eight randomised to EPA+ DHA and
one to placebo) and seven to the DHA< 2% group (all placebo). Compared with individuals
with erythrocyte< 2% change in DHA abundance, those with⩾ 2% enrichment had
significant improvements in hepatic insulin sensitivity, reduced fasting and postprandial
plasma triglyceride concentrations, decreased fasting hepatic DNL, as well as greater
appearance of 13 C from dietary fat into plasma 3-hydroxybutyrate (all P< 0.05) …
one to placebo) and seven to the DHA< 2% group (all placebo). Compared with individuals
with erythrocyte< 2% change in DHA abundance, those with⩾ 2% enrichment had
significant improvements in hepatic insulin sensitivity, reduced fasting and postprandial
plasma triglyceride concentrations, decreased fasting hepatic DNL, as well as greater
appearance of 13 C from dietary fat into plasma 3-hydroxybutyrate (all P< 0.05) …
Results:
Nine participants were stratified to DHA⩾ 2%(eight randomised to EPA+ DHA and one to placebo) and seven to the DHA< 2% group (all placebo). Compared with individuals with erythrocyte< 2% change in DHA abundance, those with⩾ 2% enrichment had significant improvements in hepatic insulin sensitivity, reduced fasting and postprandial plasma triglyceride concentrations, decreased fasting hepatic DNL, as well as greater appearance of 13 C from dietary fat into plasma 3-hydroxybutyrate (all P< 0.05).
Conclusions:
The findings from our pilot study indicate that individuals who achieved a change in erythrocyte DHA enrichment⩾ 2% show favourable changes in hepatic FA metabolism and insulin sensitivity, which may contribute to decreasing hepatic fat content.
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