Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment
G Esquerda-Canals, J Marti, G Rivera-Hernández… - MAbs, 2013 - Taylor & Francis
G Esquerda-Canals, J Marti, G Rivera-Hernández, L Giménez-Llort, S Villegas
MAbs, 2013•Taylor & FrancisThe therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A
clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found,
but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD
cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron
depletion in the DCN was regionally variable and followed a mediolateral axis of
involvement that was greatest in the fastigial nucleus, lesser in the interpositus and …
clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found,
but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD
cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron
depletion in the DCN was regionally variable and followed a mediolateral axis of
involvement that was greatest in the fastigial nucleus, lesser in the interpositus and …
The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron depletion in the DCN was regionally variable and followed a mediolateral axis of involvement that was greatest in the fastigial nucleus, lesser in the interpositus and negligible in the dentate nucleus. A sole and low intraperitoneal dose of scFv-h3D6 protected 3xTg-AD DCN neurons from death. Further studies might provide interesting information about both the potential of scFv-h3D6 as a therapeutic agent and the role of the cerebellum in AD.
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