[PDF][PDF] Predicting polygenic obesity using genetic information

RJF Loos, ACJW Janssens - Cell metabolism, 2017 - cell.com
Cell metabolism, 2017cell.com
Except in rare cases, obesity tends to be a consequence of both an unhealthy lifestyle and a
genetic susceptibility to gain weight. With more than 200 common genetic variants identified,
there is a growing interest in developing personalized preventive and treatment strategies to
predict an individual's obesity risk. We review the literature on the prediction of obesity and
show that models based on the established genetic variants have poorer predictive ability
than traditional predictors, such as family history of obesity and childhood obesity. Current …
Except in rare cases, obesity tends to be a consequence of both an unhealthy lifestyle and a genetic susceptibility to gain weight. With more than 200 common genetic variants identified, there is a growing interest in developing personalized preventive and treatment strategies to predict an individual's obesity risk. We review the literature on the prediction of obesity and show that models based on the established genetic variants have poorer predictive ability than traditional predictors, such as family history of obesity and childhood obesity. Current findings suggest that opportunities for precision medicine in common obesity may be limited.
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