[HTML][HTML] Down-regulation of Krüppel-like Factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming …
BN Davis-Dusenbery, MC Chan, KE Reno… - Journal of Biological …, 2011 - ASBMB
In the postnatal vasculature, fully differentiated and quiescent vascular smooth muscle cells
(VSMCs) in a" contractile" phenotype are required for the normal regulation of vascular tone.
The transforming growth factor-β (TGF-β) superfamily of growth factors (TGF-βs and bone
morphogenetic proteins (BMPs)) are potent inducers of contractile phenotype and mediate
(i) induction of contractile genes, and (ii) inhibition of VSMC growth and migration.
Transcription of contractile genes is positively regulated by a regulatory DNA element called …
(VSMCs) in a" contractile" phenotype are required for the normal regulation of vascular tone.
The transforming growth factor-β (TGF-β) superfamily of growth factors (TGF-βs and bone
morphogenetic proteins (BMPs)) are potent inducers of contractile phenotype and mediate
(i) induction of contractile genes, and (ii) inhibition of VSMC growth and migration.
Transcription of contractile genes is positively regulated by a regulatory DNA element called …