BDCA-2 signaling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation and antigen presentation
PS Jähn, KS Zänker, J Schmitz, A Dzionek - Cellular immunology, 2010 - Elsevier
Plasmacytoid dendritic cells (PDCs) express Toll-like receptor (TLR) 9, which mediates
recognition of microbial DNA during infection or self-DNA in autoimmune diseases.
Triggering TLR-9 in PDC induces either maturation (lysosomal TLR-9 triggering) or type I
interferon (IFN-I) production (endosomal TLR-9 triggering). PDCs also express BDCA-2
(CD303), a C-type lectin receptor (CLR) unique to these cells. CLRs appear to function in
innate immunity and microbial recognition, and may cooperate with TLRs to fine-tune …
recognition of microbial DNA during infection or self-DNA in autoimmune diseases.
Triggering TLR-9 in PDC induces either maturation (lysosomal TLR-9 triggering) or type I
interferon (IFN-I) production (endosomal TLR-9 triggering). PDCs also express BDCA-2
(CD303), a C-type lectin receptor (CLR) unique to these cells. CLRs appear to function in
innate immunity and microbial recognition, and may cooperate with TLRs to fine-tune …