Essential role of X-box binding protein-1 during endoplasmic reticulum stress in podocytes

H Hassan, X Tian, K Inoue, N Chai, C Liu… - Journal of the …, 2016 - journals.lww.com
Podocytes are terminally differentiated epithelial cells that reside along the glomerular
filtration barrier. Evidence suggests that after podocyte injury, endoplasmic reticulum stress
response is activated, but the molecular mechanisms involved are incompletely defined. In a
mouse model, we confirmed that podocyte injury induces endoplasmic reticulum stress
response and upregulated unfolded protein response pathways, which have been shown to
mitigate damage by preventing the accumulation of misfolded proteins in the endoplasmic …