[HTML][HTML] MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes …
H Fayyad-Kazan, R Rouas, M Fayyad-Kazan… - Journal of Biological …, 2012 - ASBMB
Regulatory T cells (Tregs) are characterized by a high expression of IL-2 receptor α chain
(CD25) and of forkhead box P3 (FOXP3), the latter being essential for their development and
function. Another major player in the regulatory function is the cytotoxic T-lymphocyte
associated molecule-4 (CTLA-4) that inhibits cytotoxic responses. However, the regulation of
CTLA-4 expression remains less well explored. We therefore studied the microRNA
signature of circulating CD4+ Tregs isolated from adult healthy donors and identified a …
(CD25) and of forkhead box P3 (FOXP3), the latter being essential for their development and
function. Another major player in the regulatory function is the cytotoxic T-lymphocyte
associated molecule-4 (CTLA-4) that inhibits cytotoxic responses. However, the regulation of
CTLA-4 expression remains less well explored. We therefore studied the microRNA
signature of circulating CD4+ Tregs isolated from adult healthy donors and identified a …