Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family

Y Shakur, LS Holst, TR Landstrom, M Movsesian… - 2000 - Elsevier
Publisher Summary This chapter discusses some general information about cyclic
nucleotide phosphodiesterases (PDEs). It also discusses the PDE3 gene family,
emphasizing the molecular biology, structure/function relationships, and cellular regulation
and functional roles of PDE3s, as well as physiological/pharmacological actions, therapeutic
applications, and potential benefits of PDE3 inhibitors. The major cause of concern in the
use of PDE3 inhibitors as therapeutic agents is the potential for increased mortality in …