A role for Dicer in immune regulation
BS Cobb, A Hertweck, J Smith, E O'Connor… - The Journal of …, 2006 - rupress.org
The Journal of experimental medicine, 2006•rupress.org
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we
show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T
cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of
Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by
eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg
cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous …
show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T
cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of
Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by
eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg
cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous …
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor β. These results suggest that T reg cell development involves Dicer-generated RNAs.
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