BTBR Ob/Ob mutant mice model progressive diabetic nephropathy
KL Hudkins, W Pichaiwong, T Wietecha… - Journal of the …, 2010 - journals.lww.com
There remains a need for robust mouse models of diabetic nephropathy (DN) that mimic key
features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob
leptin-deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated
triglycerides, and insulin resistance, but the renal phenotype has not been characterized.
Here, we show that these obese, diabetic mice rapidly develop morphologic renal lesions
characteristic of both early and advanced human DN. BTBR ob/ob mice developed …
features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob
leptin-deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated
triglycerides, and insulin resistance, but the renal phenotype has not been characterized.
Here, we show that these obese, diabetic mice rapidly develop morphologic renal lesions
characteristic of both early and advanced human DN. BTBR ob/ob mice developed …