Infections associated with the use of eculizumab: recommendations for prevention and prophylaxis

E Benamu, JG Montoya - Current opinion in infectious diseases, 2016 - journals.lww.com
E Benamu, JG Montoya
Current opinion in infectious diseases, 2016journals.lww.com
Eculizumab has opened new horizons in the treatment of complement-mediated disorders.
Prophylactic and immunization strategies against the risk of Nesseria spp. infections are
sound and feasible. The use of eculizumab is expanding beyond complement-mediated
diseases to transplantation and neurological disorders. Further research is needed to better
define and stratify the risk of infection and prevention strategies in patients with the latter
indications.
Summary
Eculizumab has opened new horizons in the treatment of complement-mediated disorders. Prophylactic and immunization strategies against the risk of Nesseria spp. infections are sound and feasible. The use of eculizumab is expanding beyond complement-mediated diseases to transplantation and neurological disorders. Further research is needed to better define and stratify the risk of infection and prevention strategies in patients with the latter indications.
Lippincott Williams & Wilkins