Efficacy of targeted complement inhibition in experimental C3 glomerulopathy
MM Ruseva, T Peng, MA Lasaro… - Journal of the …, 2016 - journals.lww.com
C3 glomerulopathy refers to renal disorders characterized by abnormal accumulation of C3
within the kidney, commonly along the glomerular basement membrane (GBM). C3
glomerulopathy is associated with complement alternative pathway dysregulation, which
includes functional defects in complement regulator factor H (FH). There is no effective
treatment for C3 glomerulopathy. We investigated the efficacy of a recombinant mouse
protein composed of domains from complement receptor 2 (CR2) and FH (CR2-FH) in two …
within the kidney, commonly along the glomerular basement membrane (GBM). C3
glomerulopathy is associated with complement alternative pathway dysregulation, which
includes functional defects in complement regulator factor H (FH). There is no effective
treatment for C3 glomerulopathy. We investigated the efficacy of a recombinant mouse
protein composed of domains from complement receptor 2 (CR2) and FH (CR2-FH) in two …