[HTML][HTML] Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain

Z Chen, L Guo, J Hadas, S Gutowski, SR Sprang… - Journal of Biological …, 2012 - ASBMB
Background: p115-RhoGEF can be regulated by activated Gα 13. Results: Both RGS and
DH domains of p115-RhoGEF interact with Gα 13. Conclusion: The binding of RGS to Gα 13
facilitates direct association of Gα 13 to DH to regulate its exchange activity. Significance:
RGS domains can act cooperatively with other domains to mediate effector regulation by G
proteins.