[HTML][HTML] The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid α2, 6-galactose

LM Steirer, EI Park, RR Townsend… - Journal of biological …, 2009 - ASBMB
The asialoglycoprotein receptor (ASGP-R) is an abundant, carbohydrate-specific, endocytic
receptor expressed by parenchymal cells of the liver. We recently demonstrated that the
ASGP-R mediates the clearance of glycoproteins bearing Siaα2, 6GalNAc as well as those
bearing terminal Gal or GalNAc. We now report that glycoproteins such as haptoglobin,
serum amyloid protein (SAP), and carboxylesterase that bear oligosaccharides with terminal
Siaα2, 6Gal are elevated in the plasma of ASGP-R-deficient mice. Because of their …