Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant
clinical heterogeneity. Recent advances in our understanding of the genetic, molecular, and
cellular bases of autoimmune diseases and especially SLE have led to the application of
novel and targeted treatments. Although many treatment modalities are effective in lupus-
prone mice, the situation is more complex in human subjects. This article reviews the
general approach to the therapy of SLE, focusing on current approved therapies and novel …