Thoracic aortic aneurysm and dissection
JZ Goldfinger, JL Halperin, ML Marin… - Journal of the American …, 2014 - jacc.org
JZ Goldfinger, JL Halperin, ML Marin, AS Stewart, KA Eagle, V Fuster
Journal of the American College of Cardiology, 2014•jacc.orgAortic dissection is the most devastating complication of thoracic aortic disease. In the more
than 250 years since thoracic aortic dissection was first described, much has been learned
about diseases of the thoracic aorta. In this review, we describe normal thoracic aortic size;
risk factors for dissection, including genetic and inflammatory conditions; the underpinnings
of genetic diseases associated with aneurysm and dissection, including Marfan syndrome
and the role of transforming growth factor beta signaling; data on the role for medical …
than 250 years since thoracic aortic dissection was first described, much has been learned
about diseases of the thoracic aorta. In this review, we describe normal thoracic aortic size;
risk factors for dissection, including genetic and inflammatory conditions; the underpinnings
of genetic diseases associated with aneurysm and dissection, including Marfan syndrome
and the role of transforming growth factor beta signaling; data on the role for medical …
Abstract
Aortic dissection is the most devastating complication of thoracic aortic disease. In the more than 250 years since thoracic aortic dissection was first described, much has been learned about diseases of the thoracic aorta. In this review, we describe normal thoracic aortic size; risk factors for dissection, including genetic and inflammatory conditions; the underpinnings of genetic diseases associated with aneurysm and dissection, including Marfan syndrome and the role of transforming growth factor beta signaling; data on the role for medical therapies in aneurysmal disease, including beta-blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors; prophylactic surgery for aneurysm; surgical techniques for the aortic root; and surgical and endovascular management of aneurysm and dissection for different aortic segments.
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