[HTML][HTML] Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
KSR Sastry, Y Karpova, S Prokopovich, AJ Smith… - Journal of Biological …, 2007 - ASBMB
The stress hormone epinephrine is known to elicit multiple systemic effects that include
changes in cardiovascular parameters and immune responses. However, information about
its direct action on cancer cells is limited. Here we provide evidence that epinephrine
reduces sensitivity of cancer cells to apoptosis through interaction with β 2-adrenergic
receptors. The antiapoptotic mechanism of epinephrine primarily involves phosphorylation
and inactivation of the proapoptotic protein BAD by cAMP-dependent protein kinase …
changes in cardiovascular parameters and immune responses. However, information about
its direct action on cancer cells is limited. Here we provide evidence that epinephrine
reduces sensitivity of cancer cells to apoptosis through interaction with β 2-adrenergic
receptors. The antiapoptotic mechanism of epinephrine primarily involves phosphorylation
and inactivation of the proapoptotic protein BAD by cAMP-dependent protein kinase …