The histopathology of lung allograft dysfunction associated with the development of donor-specific HLA alloantibodies
SA Yousem, A Zeevi - The American journal of surgical pathology, 2012 - journals.lww.com
The histopathology of antibody-mediated rejection in lung allografts, outside of classical
hyperacute rejection, has been poorly defined, in part because of the difficulty in identifying
potential alloantibodies and in separating alloreactive and nonspecific complement-
mediated reactions. In this study, we looked at lung biopsies coinciding with the
development of anti-human leukocyte antigen (anti-HLA) antibodies and lung dysfunction in
a diverse group of lung transplant recipients over a 3-year period. We identified 23 patients …
hyperacute rejection, has been poorly defined, in part because of the difficulty in identifying
potential alloantibodies and in separating alloreactive and nonspecific complement-
mediated reactions. In this study, we looked at lung biopsies coinciding with the
development of anti-human leukocyte antigen (anti-HLA) antibodies and lung dysfunction in
a diverse group of lung transplant recipients over a 3-year period. We identified 23 patients …