Genotype-guided vs clinical dosing of warfarin and its analogues: meta-analysis of randomized clinical trials
K Stergiopoulos, DL Brown - JAMA internal medicine, 2014 - jamanetwork.com
Importance Significant variations in dose requirements of warfarin and its analogues
(acenocoumarol and phenprocoumon) make selecting the appropriate dose for an
individual patient difficult. Genetic factors account for approximately one-third of the variation
in dose requirement. The clinical usefulness of genotype-guided dosing of warfarin has
been previously assessed in randomized clinical trials that were limited by lack of power and
inconsistent results. Objective To compare genotype-guided initial dosing of warfarin and its …
(acenocoumarol and phenprocoumon) make selecting the appropriate dose for an
individual patient difficult. Genetic factors account for approximately one-third of the variation
in dose requirement. The clinical usefulness of genotype-guided dosing of warfarin has
been previously assessed in randomized clinical trials that were limited by lack of power and
inconsistent results. Objective To compare genotype-guided initial dosing of warfarin and its …