[HTML][HTML] Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4
E Aberg, M Perander, B Johansen, C Julien… - Journal of biological …, 2006 - ASBMB
MAPK-activated protein kinase 5 (MK5) was recently identified as a physiological substrate
of the atypical MAPK ERK3. Complex formation between ERK3 and MK5 results in
phosphorylation and activation of MK5, concomitant stabilization of ERK3, and the nuclear
exclusion of both proteins. However, ablation of ERK3 in HeLa cells using small interfering
RNA or in fibroblasts derived from ERK3 null mice reduces the activity of endogenous MK5
by only 50%, suggesting additional mechanisms of MK5 regulation. Here we identify the …
of the atypical MAPK ERK3. Complex formation between ERK3 and MK5 results in
phosphorylation and activation of MK5, concomitant stabilization of ERK3, and the nuclear
exclusion of both proteins. However, ablation of ERK3 in HeLa cells using small interfering
RNA or in fibroblasts derived from ERK3 null mice reduces the activity of endogenous MK5
by only 50%, suggesting additional mechanisms of MK5 regulation. Here we identify the …