[HTML][HTML] Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
CR Weber, DR Raleigh, L Su, L Shen… - Journal of Biological …, 2010 - ASBMB
Intestinal barrier function is reduced in inflammatory bowel disease (IBD). Tumor necrosis
factor (TNF) and interleukin (IL)-13, which are up-regulated in IBD, induce barrier defects
that are associated with myosin light chain kinase (MLCK) activation and increased claudin-
2 expression, respectively, in cultured intestinal epithelial monolayers. Here we report that
these independent signaling pathways have distinct effects on tight junction barrier
properties and interact in vivo. MLCK activation alters size selectivity to enhance …
factor (TNF) and interleukin (IL)-13, which are up-regulated in IBD, induce barrier defects
that are associated with myosin light chain kinase (MLCK) activation and increased claudin-
2 expression, respectively, in cultured intestinal epithelial monolayers. Here we report that
these independent signaling pathways have distinct effects on tight junction barrier
properties and interact in vivo. MLCK activation alters size selectivity to enhance …