[HTML][HTML] Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease

SA Blair, SV Kane, DR Clayburgh, JR Turner - Laboratory investigation, 2006 - Elsevier
The intestinal epithelial barrier is frequently disrupted in inflammatory bowel disease (IBD)
and this has been proposed to play a role in disease pathogenesis and reactivation. In vitro
studies show that cytokine-induced epithelial barrier dysfunction can be mediated by
increased myosin light chain kinase (MLCK) expression and subsequent myosin II
regulatory light chain (MLC) phosphorylation. However, this has never been examined in
human disease. The aim of these studies, therefore, was to determine whether MLCK is …