[HTML][HTML] Identification of preferential CD4+ T-cell targets for HIV infection in the cervix
VR Joag, LR McKinnon, J Liu, ST Kidane, MH Yudin… - Mucosal …, 2016 - Elsevier
A better understanding of the cellular targets of HIV infection in the female genital tract may
inform HIV prevention efforts. Proposed correlates of cellular susceptibility include the HIV
co-receptor CCR5, peripheral homing integrins, and immune activation. We used a CCR5-
tropic pseudovirus to quantify HIV entry into unstimulated endocervical CD4+ T cells
collected by cytobrush. Virus entry was threefold higher into cervix-derived CD4+ T cells
than blood, but was strongly correlated between these two compartments. Cervix-derived …
inform HIV prevention efforts. Proposed correlates of cellular susceptibility include the HIV
co-receptor CCR5, peripheral homing integrins, and immune activation. We used a CCR5-
tropic pseudovirus to quantify HIV entry into unstimulated endocervical CD4+ T cells
collected by cytobrush. Virus entry was threefold higher into cervix-derived CD4+ T cells
than blood, but was strongly correlated between these two compartments. Cervix-derived …