Novel universal influenza virus vaccine approaches
F Krammer - Current opinion in virology, 2016 - Elsevier
Highlights•Two different types of stalk-based universal influenza virus vaccine candidates—
chimeric hemagglutinins and headless hemagglutinins—are currently in development.•The
two types of vaccines might induce a different antibody profile.•Efficacy of anti-stalk
antibodies in vivo is high despite low in vitro neutralization potential.•Long lasting immunity
is important for universal influenza virus vaccines.Seasonal influenza virus vaccines have to
be re-formulated and re-administered on an annual basis due to antigenic drift of the …
chimeric hemagglutinins and headless hemagglutinins—are currently in development.•The
two types of vaccines might induce a different antibody profile.•Efficacy of anti-stalk
antibodies in vivo is high despite low in vitro neutralization potential.•Long lasting immunity
is important for universal influenza virus vaccines.Seasonal influenza virus vaccines have to
be re-formulated and re-administered on an annual basis due to antigenic drift of the …