[HTML][HTML] Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy
RA Hanna, MN Quinsay, AM Orogo, K Giang… - Journal of Biological …, 2012 - ASBMB
Autophagy plays an important role in cellular quality control and is responsible for removing
protein aggregates and dysfunctional organelles. Bnip3 is an atypical BH3-only protein that
is known to cause mitochondrial dysfunction and cell death. Interestingly, Bnip3 can also
protect against cell death by inducing mitochondrial autophagy. The mechanism for this
process, however, remains poorly understood. Bnip3 contains a C-terminal transmembrane
domain that is essential for homodimerization and proapoptotic function. In this study, we …
protein aggregates and dysfunctional organelles. Bnip3 is an atypical BH3-only protein that
is known to cause mitochondrial dysfunction and cell death. Interestingly, Bnip3 can also
protect against cell death by inducing mitochondrial autophagy. The mechanism for this
process, however, remains poorly understood. Bnip3 contains a C-terminal transmembrane
domain that is essential for homodimerization and proapoptotic function. In this study, we …