Assays for necroptosis and activity of RIP kinases
A Degterev, W Zhou, JL Maki, J Yuan - Methods in enzymology, 2014 - Elsevier
Necrosis is a primary form of cell death in a variety of human pathologies. The deleterious
nature of necrosis, including its propensity to promote inflammation, and the relative lack of
the cells displaying necrotic morphology under physiologic settings, such as during
development, have contributed to the notion that necrosis represents a form of pathologic
stress-induced nonspecific cell lysis. However, this notion has been challenged in recent
years by the discovery of a highly regulated form of necrosis, termed regulated necrosis or …
nature of necrosis, including its propensity to promote inflammation, and the relative lack of
the cells displaying necrotic morphology under physiologic settings, such as during
development, have contributed to the notion that necrosis represents a form of pathologic
stress-induced nonspecific cell lysis. However, this notion has been challenged in recent
years by the discovery of a highly regulated form of necrosis, termed regulated necrosis or …