The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?

JM Brown, DJ Carlson, DJ Brenner - International Journal of Radiation …, 2014 - Elsevier
Stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT), also known
as stereotactic ablative radiation therapy (SABR), are rapidly becoming accepted practice for
the radiation therapy of certain tumors. Typically, SRS and SBRT involve the delivery of 1 or
a few large-dose fractions of 8 to 30 Gy per fraction: a major paradigm shift from radiation
therapy practice over the past 90 years, when, with relatively large amounts of normal
tissues receiving high doses, the goal was to maximize tumor response for an acceptable …