Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in γ-irradiated CHO cells
The repair of DNA double-strand breaks (DSBs) by homologous recombinational repair
(HRR) underlies the high radioresistance and low mutability observed in S-phase
mammalian cells. To evaluate the contributions of HRR and non-homologous end-joining
(NHEJ) to overall DSB repair capacity throughout the cell cycle after γ-irradiation, we
compared HRR-deficient RAD51D-knockout 51D1 to CgRAD51D-complemented 51D1
(51D1. 3) CHO cells for survival and chromosomal aberrations (CAs). Asynchronous …
(HRR) underlies the high radioresistance and low mutability observed in S-phase
mammalian cells. To evaluate the contributions of HRR and non-homologous end-joining
(NHEJ) to overall DSB repair capacity throughout the cell cycle after γ-irradiation, we
compared HRR-deficient RAD51D-knockout 51D1 to CgRAD51D-complemented 51D1
(51D1. 3) CHO cells for survival and chromosomal aberrations (CAs). Asynchronous …