The nitric oxide-endothelin-1 connection
D Alonso, MW Radomski - Heart failure reviews, 2003 - Springer
D Alonso, MW Radomski
Heart failure reviews, 2003•SpringerNitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play
important roles in vascular homeostasis. This review is focused on the role and reciprocal
interactions between NO and ET-1 in health and diseases associated with endothelium
dysfunction. We will also discuss the clinical significance of NO donors and drugs that
antagonize ET receptors.
important roles in vascular homeostasis. This review is focused on the role and reciprocal
interactions between NO and ET-1 in health and diseases associated with endothelium
dysfunction. We will also discuss the clinical significance of NO donors and drugs that
antagonize ET receptors.
Abstract
Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.
Springer