[HTML][HTML] Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle–regulated exocytosis in mast cells
BA Gutierrez, MA Chavez, AI Rodarte… - Journal of Biological …, 2018 - ASBMB
Mast cells (MCs) play pivotal roles in many inflammatory conditions including infections,
anaphylaxis, and asthma. MCs store immunoregulatory compounds in their large
cytoplasmic granules and, upon stimulation, secrete them via regulated exocytosis.
Exocytosis in many cells requires the participation of Munc18 proteins (also known as
syntaxin-binding proteins), and we found that mature MCs express all three mammalian
isoforms: Munc18-1,-2, and-3. To study their functions in MC effector responses and test the …
anaphylaxis, and asthma. MCs store immunoregulatory compounds in their large
cytoplasmic granules and, upon stimulation, secrete them via regulated exocytosis.
Exocytosis in many cells requires the participation of Munc18 proteins (also known as
syntaxin-binding proteins), and we found that mature MCs express all three mammalian
isoforms: Munc18-1,-2, and-3. To study their functions in MC effector responses and test the …