Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites

AB Shinde, RK Baboota, S Denis, U Loizides-Mangold… - Mitochondrion, 2018 - Elsevier
The structural disruption of the mitochondrial inner membrane in hepatocytes lacking
functional peroxisomes along with selective impairment of respiratory complexes and
depletion of mitochondrial DNA was previously reported. In search for the molecular origin of
these mitochondrial alterations, we here show that these are tissue selective as they do
neither occur in peroxisome deficient brain nor in peroxisome deficient striated muscle.
Given the hepatocyte selectivity, we investigated the potential involvement of metabolites …