Peroxisome deficient aP2–Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone
K Martens, A Bottelbergs, A Peeters, F Jacobs… - Molecular genetics and …, 2012 - Elsevier
Peroxisomes are essential for intermediary lipid metabolism, but the role of these organelles
has been primarily studied in the liver. We recently generated aP2–Pex5 conditional
knockout mice that due to the nonselectivity of the aP2 promoter, not only had dysfunctional
peroxisomes in the adipose tissue but also in the central and peripheral nervous system,
besides some other tissues. Peroxisomes were however intact in the liver, heart, pancreas
and muscle. Surprisingly, these mice not only showed dysfunctional white adipose tissue …
has been primarily studied in the liver. We recently generated aP2–Pex5 conditional
knockout mice that due to the nonselectivity of the aP2 promoter, not only had dysfunctional
peroxisomes in the adipose tissue but also in the central and peripheral nervous system,
besides some other tissues. Peroxisomes were however intact in the liver, heart, pancreas
and muscle. Surprisingly, these mice not only showed dysfunctional white adipose tissue …
