[HTML][HTML] Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization

HM Guardiola-Diaz, S Rehnmark, N Usuda… - Journal of Biological …, 1999 - ASBMB
Brown adipose tissue (BAT) hyperplasia is a fundamental physiological response to cold; it
involves an acute phase of mitotic cell growth followed by a prolonged differentiation phase.
Peroxisome proliferator-activated receptors (PPARs) are key regulators of fatty acid
metabolism and adipocyte differentiation and may therefore mediate important metabolic
changes during non-shivering thermogenesis. In the present study we have investigated
PPAR mRNA expression in relation to peroxisome proliferation in rat BAT during cold …