Altered plasma neutrophil microparticle levels have recently been implicated in a number of
vascular and inflammatory diseases, yet our understanding of their actions is very limited.
Herein, we investigate the proteome of neutrophil microparticles in order to shed light on
their biological actions. Stimulation of human neutrophils, either in suspension or adherent
to an endothelial monolayer, led to the production of microparticles containing> 400 distinct
proteins with only 223 being shared by the two subsets. For instance, postadherent …