We have recently developed a general theoretical framework for transvascular exchange
and extravascular transport of fluid and macromolecules in tumors. The model was applied
to a homogeneous, alymphatic tumor with no extravascular binding. For this simplified
system, the interstitial pressure was found to be a major contributing factor to the
heterogeneous distribution of macromolecules within solid tumors. A steep pressure
gradient was predicted at the periphery of the tumor. Our recent experiments have verified …