[HTML][HTML] Hypoxia-inducible factors in physiology and medicine

GL Semenza - Cell, 2012 - cell.com
GL Semenza
Cell, 2012cell.com
Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs)
are transcriptional activators that function as master regulators of oxygen homeostasis in all
metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in
many physiological systems, determining pathological consequences of HIF dysregulation
in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
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