[HTML][HTML] Synergistic deposition of C4d by complement‐activating and non‐activating antibodies in cardiac transplants
K Murata, K Fox‐Talbot, Z Qian, K Takahashi… - American Journal of …, 2007 - Elsevier
The role of non‐complement‐activating alloantibodies in humoral graft rejection is unclear.
We hypothesized that the non‐complement‐activating alloantibodies synergistically activate
complement in combination with complement‐activating antibodies. B10. A hearts were
transplanted into immunoglobulin knock out (Ig‐KO) mice reconstituted with monoclonal
antibodies to MHC class I antigens. In allografts of unreconstituted Ig‐KO recipients, no C4d
was detected. Similarly, reconstitution with IgG1 or low dose IgG2b alloantibodies did not …
We hypothesized that the non‐complement‐activating alloantibodies synergistically activate
complement in combination with complement‐activating antibodies. B10. A hearts were
transplanted into immunoglobulin knock out (Ig‐KO) mice reconstituted with monoclonal
antibodies to MHC class I antigens. In allografts of unreconstituted Ig‐KO recipients, no C4d
was detected. Similarly, reconstitution with IgG1 or low dose IgG2b alloantibodies did not …