[HTML][HTML] Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via stimulator of interferon genes
A Iracheta-Vellve, J Petrasek, B Gyongyosi… - Journal of Biological …, 2016 - ASBMB
Fibrosis, driven by inflammation, marks the transition from benign to progressive stages of
chronic liver diseases. Although inflammation promotes fibrogenesis, it is not known whether
other events, such as hepatocyte death, are required for the development of fibrosis.
Interferon regulatory factor 3 (IRF3) regulates hepatocyte apoptosis and production of type I
IFNs. In the liver, IRF3 is activated via Toll-like receptor 4 (TLR4) signaling or the
endoplasmic reticulum (ER) adapter, stimulator of interferon genes (STING). We …
chronic liver diseases. Although inflammation promotes fibrogenesis, it is not known whether
other events, such as hepatocyte death, are required for the development of fibrosis.
Interferon regulatory factor 3 (IRF3) regulates hepatocyte apoptosis and production of type I
IFNs. In the liver, IRF3 is activated via Toll-like receptor 4 (TLR4) signaling or the
endoplasmic reticulum (ER) adapter, stimulator of interferon genes (STING). We …