Maintaining physical connections between the nucleus and the cytoskeleton is important for
many cellular processes that require coordinated movement and positioning of the nucleus.
Nucleo-cytoskeletal coupling is also necessary to transmit extracellular mechanical stimuli
across the cytoskeleton to the nucleus, where they may initiate mechanotransduction events.
The LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, formed by the interaction of
nesprins and SUN proteins at the nuclear envelope, can bind to nuclear and cytoskeletal …