[HTML][HTML] Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus
ML Martowicz, JA Grass, ME Boyer, H Guend… - Journal of Biological …, 2005 - ASBMB
Given the simplicity of the DNA sequence that mediates binding of GATA transcription
factors, GATA motifs reside throughout chromosomal DNA. However, chromatin
immunoprecipitation analysis has revealed that GATA-1 discriminates exquisitely among
these sites. GATA-2 selectively occupies the–2.8-kilobase (kb) region of the GATA-2 locus in
the active state despite there being numerous GATA motifs throughout the locus. The GATA-
1-mediated displacement of GATA-2 is tightly coupled to repression of GATA-2 transcription …
factors, GATA motifs reside throughout chromosomal DNA. However, chromatin
immunoprecipitation analysis has revealed that GATA-1 discriminates exquisitely among
these sites. GATA-2 selectively occupies the–2.8-kilobase (kb) region of the GATA-2 locus in
the active state despite there being numerous GATA motifs throughout the locus. The GATA-
1-mediated displacement of GATA-2 is tightly coupled to repression of GATA-2 transcription …