[HTML][HTML] Vismodegib exerts targeted efficacy against recurrent sonic hedgehog–subgroup medulloblastoma: results from phase II pediatric brain tumor consortium …

GW Robinson, BA Orr, G Wu… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
GW Robinson, BA Orr, G Wu, S Gururangan, T Lin, I Qaddoumi, RJ Packer, S Goldman…
Journal of Clinical Oncology, 2015ncbi.nlm.nih.gov
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup
Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B
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Abstract
Purpose
Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB).
ncbi.nlm.nih.gov