[HTML][HTML] β-subunits promote the expression of CaV2. 2 channels by reducing their proteasomal degradation
D Waithe, L Ferron, KM Page, K Chaggar… - Journal of Biological …, 2011 - ASBMB
The β-subunits of voltage-gated calcium channels regulate their functional expression and
properties. Two mechanisms have been proposed for this, an effect on gating and an
enhancement of expression. With respect to the effect on expression, β-subunits have been
suggested to enhance trafficking by masking an unidentified endoplasmic reticulum (ER)
retention signal. Here we have investigated whether, and how, β-subunits affect the level of
Ca V 2.2 channels within somata and neurites of cultured sympathetic neurons. We have …
properties. Two mechanisms have been proposed for this, an effect on gating and an
enhancement of expression. With respect to the effect on expression, β-subunits have been
suggested to enhance trafficking by masking an unidentified endoplasmic reticulum (ER)
retention signal. Here we have investigated whether, and how, β-subunits affect the level of
Ca V 2.2 channels within somata and neurites of cultured sympathetic neurons. We have …