Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

X Chen, H Lu, DL Rateri, LA Cassis… - Current opinion in …, 2013 - Elsevier
Angiotensin II (AngII) has been invoked as a principal mediator for the development and
progression of both thoracic and abdominal aortic aneurysms. While there is consistency in
experimental and clinical studies that overactivation of the renin angiotensin system
promotes aortic aneurysm development, there are many unknowns regarding the
mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in
both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While …