[PDF][PDF] Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study

T Hasi, L Hao, L Yang, XL Su - Genet Mol Res, 2011 - geneticsmr.com
T Hasi, L Hao, L Yang, XL Su
Genet Mol Res, 2011geneticsmr.com
Mongolians are known as heavy drinkers, and they have a high incidence of essential
hypertension, which may be an associated pathology. We examined a possible association
of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2)
gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs671 of ALDH2
was detected by TaqMan PCR in 91 essential hypertensive patients (44 males and 47
females) and 70 healthy Mongolians (37 males and 33 females). Frequencies of the …
Abstract
Mongolians are known as heavy drinkers, and they have a high incidence of essential hypertension, which may be an associated pathology. We examined a possible association of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs671 of ALDH2 was detected by TaqMan PCR in 91 essential hypertensive patients (44 males and 47 females) and 70 healthy Mongolians (37 males and 33 females). Frequencies of the ALDH2* 1/1 genotype and the ALDH2* 1 allele in patients (91.2 and 95.6%, respectively) were significantly higher than in controls (78.6 and 89.3%; P< 0.05), while frequencies of ALDH2* 1/2 genotype and ALDH2* 2 allele in patients (8.79 and 4.4%) were much lower than in controls (21.4 and 10.7%; P< 0.05). Frequencies of ALDH2* 1/1 genotype and ALDH2* 1 allele in female patients (95.8 and 94.9%) were higher than in female controls (70.0
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